PDRN: The Salmon DNA Skincare Trend You’ll Want to Know About
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Hello Beauty Professionals!
We’re back with another exciting and education-packed blog—and this time, we’re diving into one of the most buzzed-about ingredients in Korean clinical skincare right now: PDRN (Polydeoxyribonucleotide), also known as “salmon DNA.”
While the name might sound like the latest K-beauty trend, PDRN is far more than a fad. Backed by decades of clinical use in regenerative medicine, this powerful ingredient is gaining serious traction in aesthetic skincare for its ability to revitalize, repair, and restore compromised skin .
Once used mainly in Korean dermatology clinics through injectable “skin boosters,” PDRN is now more widely available through non-invasive formats —including microneedling ampoules, serums, and creams and lots of home care products.
So what makes it so special? And is it worth adding to your treatment menu—or recommending to your clients? Let’s take a closer look.
What is PDRN?
PDRN is a DNA-based ingredient made from purified salmon sperm cells. Don’t let the source throw you off— salmon DNA is biocompatible, meaning it works harmoniously with human skin, and is rich in the nucleotides that promote healing.
It’s widely used in dermatology and aesthetic medicine, particularly in treatments that address wounds, burns, surgical recovery, and more recently, skin aging and sensitivity.
Where Did PDRN Come From?
In Korea, it started in dermtology clinics with dermatologist-administered PDRN injections, often called as “healer shots.” These treatments became wildly popular for their ability to plump up the skin, improve elasticity, and reduce redness or scarring — all without downtime.
While PDRN began as an injectable-only trend, it's now more accessible than ever. You can incorporate it into your routine through microneedling, which enhances absorption by creating micro-channels in the skin, or even with topical application alone, which still delivers visible benefits like increased hydration and improved skin resilience.
As Korean dermatologists and skincare influencers began showcasing their radiant, glass-skin transformations using PDRN, the ingredient quickly went viral—making its way from clinical settings into the mainstream as one of the most buzzed-about skincare innovations of the year.
Key Benefits of PDRN for Your Skin
Skin Regeneration :
PDRN helps rebuild tissue and repair skin damage by boosting DNA activity and promoting faster skin cell turnover.
Deep Hydration + Barrier Repair :
PDRN has a soothing, replenishing effect that helps restore the skin’s barrier and improve long-term hydration.
Collagen & Elasticity Support :
By accelerating regeneration and hydration, PDRN helps reinforce the skin barrier , making it more resistant to environmental stressors and inflammation.
Anti-Inflammatory Benefits :
Especially helpful for those with sensitive or post-treatment skin. PDRN calms irritation and helps accelerate recovery.
How Professionals Use PDRN in Treatments
PDRN is incredibly versatile and can be used across the face, neck, and even delicate areas. Some of the most requested treatment zones include: Under Eye Area, Smile Lines, Forehead, and Jawline.
PDRN's regenerative effects make it a favorite for:
Reducing under-eye bags
Improving skin density
Smoothing fine lines and crepiness
Loss of elasticity around the jawline and nasolabial folds
Wrinkles and volume loss on the forehead and temples
Microneedling with PDRN
One of the most effective ways to use PDRN professionally is through microneedling. Unlike older injectable approaches that carried higher risks or were more invasive, this method offers a safer and more comfortable way to deliver PDRN—allowing the ingredient to penetrate deeply and effectively trigger collagen production and skin renewal. Clients can expect smoother, firmer, and more hydrated skin, making it a highly rewarding treatment with minimal downtime.
Topical Skincare
PDRN is now available in professional-grade skincare that can be applied topically — no injections required. These products are:
Perfect for sensitive clients
Great for post-procedure recovery
Easy to incorporate into home care routines
What Skin Concerns Does It Help With?
PDRN is ideal for clients dealing with:
Post-microneedling or post-laser recovery
Thinning or aging skin
Dehydrated or barrier-compromised skin
Under-eye concerns and fine lines
Clients who can’t tolerate retinoids or acids
Our Recommended PDRN Skincare Products
We believe in formulas that combine science-backed ingredients with real-world results. Below are some of the best PDRN-infused products available at Pure Raum—trusted by estheticians and loved by clients.
Medipair Collagen Veil Collection
This luxurious collection is designed for soothing, strengthening skin barrier, and hydrating the skin. Infused with PDRN, collagen, and calming botanical extracts, it offers full-circle care for those recovering from treatments or struggling with weakened skin.
Collagen Veil Line includes Collagen Veil Mist, Collagen Veil Ampoule, Collagen Veil Cream, and Collagen Veil Mask.
This is a high-performance ampoule formulated for professional use, that contains 200,000 ppm of PDRN, 100,000 ppm of umbilical stem cell culture, 250+ growth factors, high concentration of hyaluronic acid.
It’s a top choice for microneedling or post-treatment application, supporting firmness, elasticity, and regeneration at every layer of the skin.
This viral Korean overnight hydrogel mask uses PDRN, peptides, and niacinamide to visibly improve elasticity and texture while you sleep. The hydrogel base adheres like a second skin, melting into the skin with body heat for optimal absorption.
No mess, no residue—just smoother, brighter, glowier skin by morning.
This innovative lifting treatment uses medical-grade PCL threads with PDRN, collagen, and silk amino acids to firm and lift skin. The two-step system features a lattice-structured melting thread mask to lift sagging skin lines, followed by a melting gel mask that delivers concentrated nutrients for a visibly lifted, healthier complexion.
Quick, effective, and with minimal downtime—experience a more sculpted, youthful, and lifted appearance that lasts.
This ampoule delivers deep hydration with three types of hyaluronic acid that absorb into different skin layers. It also contains PDRN and palmitoyl hexapeptide-12 to help improve skin elasticity and support regeneration.
Lightweight and fast-absorbing, it keeps skin plump, smooth, and healthy.
Conclusion: PDRN Is Worth The Hype!
PDRN is not just a trendy name—it’s a clinically validated ingredient that offers real benefits for skin regeneration, hydration, and long-term resilience.
Although it began with injectables, today’s formulations allow you to experience its effects through gentler, more accessible methods like microneedling or even without any skin penetration.
If your clients are looking for advanced skin results without harsh actives or downtime, PDRN is a smart, effective addition to your treatment room and retail shelf.
Thank you for reading our blog! We’ll be back soon with more exciting insights and professional skincare knowledge to support your practice.
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